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Descriptor English: Sirtuin 1
Descriptor Spanish: Sirtuina 1
Descriptor sirtuina 1
Entry term(s) Sirt1
Scope note: Miembro de la familia de las sirtuinas que se encuentra principalmente en el NÚCLEO CELULAR. Se trata de una desacetilasa dependiente de NAD con especificidad para las HISTONAS y para diversas proteínas que intervienen en la regulación génica. 
Descriptor Portuguese: Sirtuína 1
Descriptor French: Sirtuine-1
Entry term(s): Silent Mating Type Information Regulation 2 Homolog 1
Sirt1
Tree number(s): D08.811.277.087.520.200.650.100
D12.776.476.900.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056564
Scope note: A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.1.-
Previous Indexing: Histone Deacetylases (2002-2006)
Sirtuins (2007-2009)
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53587
Unique ID: D056564
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/14
Sirtuin 1 - Preferred
Concept UI M0527779
Scope note A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.
Preferred term Sirtuin 1
Entry term(s) Silent Mating Type Information Regulation 2 Homolog 1
Sirt1



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