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Descriptor English: Sirtuin 2
Descriptor Spanish: Sirtuina 2
Descriptor sirtuina 2
Entry term(s) Sirt2
Scope note: Miembro de la familia de las sirtuinas que se encuentra principalmente en el CITOPLASMA. Es una enzima multifuncional con actividad desacetilasa dependiente de NAD específica para las HISTONAS y actividad mono-ADP-ribosiltransferasa. 
Descriptor Portuguese: Sirtuína 2
Descriptor French: Sirtuine-2
Entry term(s): Silent Mating Type Information Regulation 2 Homolog 2
Sirt2
Tree number(s): D08.811.277.087.520.200.650.200
D08.811.913.400.725.115.961.200
D12.776.476.900.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D056565
Scope note: A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.1.-
Previous Indexing: Histone Deacetylases (2002-2006)
Sirtuins (2007-2009)
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53588
Unique ID: D056565
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/14
Sirtuin 2 - Preferred
Concept UI M0527790
Scope note A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
Preferred term Sirtuin 2
Entry term(s) Silent Mating Type Information Regulation 2 Homolog 2
Sirt2



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