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Descriptor English: Class Ia Phosphatidylinositol 3-Kinase
Descriptor Spanish: Fosfatidilinositol 3-Quinasa Clase Ia
Descriptor fosfatidilinositol 3-cinasa de clase Ia
Entry term(s) fosfatidilinositol 3-cinasas de clase Ia
Scope note: Subclase de fosfatidilinositol 3 cinasa que incluye enzimas formadas por la heterodimerización de una subunidad catalíticca p110 y una subunidad reguladora p85, p55 o p50. Esta subclase de enzimas es una diana en la via anterógrada de los RECEPTORES DE TIROSINA CINASA y de RECEPTORES ACOPLADOS A PROTEÍNA G.
Descriptor Portuguese: Classe Ia de Fosfatidilinositol 3-Quinase
Descriptor French: Phosphatidylinositol 3-kinase de classe Ia
Entry term(s): Class Ia Phosphatidylinositol 3 Kinase
Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit
Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit
Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit
Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit
Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit
Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit
Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit
Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit
Class Ia Phosphatidylinositol 3 Kinases
Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit
Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit
Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit
Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit
Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit
Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit
Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit
Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit
Class Ia Phosphatidylinositol 3-Kinases
Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide
Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide
Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide
PI-3K alpha-P85 Subunit
Phosphatidylinositol 3 Kinase, Class Ia
Phosphatidylinositol 3-Kinase, Class Ia
Phosphoinositide 3 Kinase, Regulatory Subunit 1
Phosphoinositide 3 Kinase, Regulatory Subunit 2
Phosphoinositide 3 Kinase, Regulatory Subunit 3
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide
Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide
Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide
Phosphoinositide-3-Kinase, Regulatory Subunit 1
Phosphoinositide-3-Kinase, Regulatory Subunit 2
Phosphoinositide-3-Kinase, Regulatory Subunit 3
alpha-P85 Subunit, PI-3K
p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase
p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase
p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase
p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
Tree number(s): D08.811.913.696.620.500.100.100.100
D08.811.913.696.620.500.200.100.100
D12.776.476.556.100.100.100
D12.776.476.556.200.100.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D058543
Scope note: A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.1.137
Previous Indexing: Phosphatidylinositol 3-Kinases (1998-2010)
Public MeSH Note: 2011; for ALPHA-P85 SUBUNIT, PI-3K see PHOSPHATIDYLINOSITOL 3-KINASE 1998-2010
History Note: 2011; for ALPHA-P85 SUBUNIT, PI-3K use PHOSPHATIDYLINOSITOL 3-KINASES 1998-2010
DeCS ID: 54045
Unique ID: D058543
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Class Ia Phosphatidylinositol 3-Kinase - Preferred
Concept UI M0543148
Scope note A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.
Preferred term Class Ia Phosphatidylinositol 3-Kinase
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase
Class Ia Phosphatidylinositol 3 Kinases
Class Ia Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3 Kinase, Class Ia
Phosphatidylinositol 3-Kinase, Class Ia
Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit - Narrower
Concept UI M0543151
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit
Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide
p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit - Narrower
Concept UI M0543152
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit
Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide
p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit - Narrower
Concept UI M0543156
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit
Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide
Phosphoinositide 3 Kinase, Regulatory Subunit 2
Phosphoinositide-3-Kinase, Regulatory Subunit 2
p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit - Narrower
Concept UI M0543158
Scope note A 55kDa variant protein resulting from alternatively-splicing of the phosphoinositide-3-Kinase, regulatory subunit 1mRNA.
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit
p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit - Narrower
Concept UI M0543157
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit
Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide
Phosphoinositide 3 Kinase, Regulatory Subunit 3
Phosphoinositide-3-Kinase, Regulatory Subunit 3
p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase
p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit - Narrower
Concept UI M0543153
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit
Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide
PI-3K alpha-P85 Subunit
Phosphoinositide 3 Kinase, Regulatory Subunit 1
Phosphoinositide-3-Kinase, Regulatory Subunit 1
alpha-P85 Subunit, PI-3K
p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit - Narrower
Concept UI M0543150
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide
p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase
Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit - Narrower
Concept UI M0543159
Scope note A 50kDa variant protein resulting from alternatively-splicing of the phosphoinositide-3-Kinase, regulatory subunit 1mRNA.
Preferred term Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit
Entry term(s) Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit
p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase
p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase



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