| Descriptor English: | Endoplasmic Reticulum-Associated Degradation | ||||||
| Descriptor Spanish: |
Degradación Asociada con el Retículo Endoplásmico
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| Descriptor Portuguese: | Degradação Associada com o Retículo Endoplasmático | ||||||
| Descriptor French: | Dégradation associée au réticulum endoplasmique | ||||||
| Entry term(s): |
Degradation, Endoplasmic Reticulum-Associated ERAD Pathway ERAD Pathways Endoplasmic Reticulum Associated Degradation Pathway, ERAD Pathways, ERAD Reticulum-Associated Degradation, Endoplasmic |
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| Tree number(s): |
G02.111.660.871.790.600.962.500 G02.111.691.600.850.500 G03.734.871.790.600.850.500 G04.434.500.500 G05.308.670.600.850.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D060746 | ||||||
| Scope note: | A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME. |
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| Allowable Qualifiers: |
DE drug effects GE genetics IM immunology PH physiology RE radiation effects |
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| Previous Indexing: |
Protein Folding (1995-2011) |
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| Public MeSH Note: | 2012 |
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| History Note: | 2012 |
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| Related: |
Endoplasmic Reticulum Stress
MeSH Proteolysis MeSH Ubiquitination MeSH | ||||||
| DeCS ID: | 54774 | ||||||
| Unique ID: | D060746 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2012/01/01 | ||||||
| Date of Entry: | 2011/06/24 | ||||||
| Revision Date: | 2016/06/23 |
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PHENOMENA AND PROCESSES
Chemical Phenomena [G02]Chemical Phenomena -
PHENOMENA AND PROCESSES
Chemical Phenomena [G02]Chemical Phenomena -
PHENOMENA AND PROCESSES
Metabolism [G03]Metabolism -
PHENOMENA AND PROCESSES
Cell Physiological Phenomena [G04]Cell Physiological Phenomena -
PHENOMENA AND PROCESSES
Genetic Phenomena [G05]Genetic Phenomena
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Endoplasmic Reticulum-Associated Degradation
- Preferred
| Concept UI |
M0555322 |
| Scope note | A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME. |
| Preferred term | Endoplasmic Reticulum-Associated Degradation |
| Entry term(s) |
Degradation, Endoplasmic Reticulum-Associated ERAD Pathway ERAD Pathways Endoplasmic Reticulum Associated Degradation Pathway, ERAD Pathways, ERAD Reticulum-Associated Degradation, Endoplasmic |
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