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Descriptor English: Voltage-Gated Sodium Channel beta-1 Subunit
Descriptor Spanish: Subunidad beta-1 de Canal de Sodio Activado por Voltaje
Descriptor subunidades beta-1 de los canales del sodio dependientes de voltaje
Scope note: Subunidad beta de los canales del sodio dependientes de voltaje, que se expresa abundantemente en el MÚSCULO ESTRIADO, el CORAZÓN, y el CEREBRO. No muestra asociación covalente con las subunidades alfa dependientes de voltaje. Defectos del gen SCN1B, que codifica esta subunidad beta, están asociados con epilepsia generalizada con convulsiones febriles plus tipo 1, y el síndrome de Brugada 5.
Descriptor Portuguese: Subunidade beta-1 do Canal de Sódio Disparado por Voltagem
Descriptor French: Sous-unité bêta-1 des canaux sodiques voltage-dépendants
Entry term(s): SCN1B Sodium Channel beta Subunit
Voltage Gated Sodium Channel beta 1 Subunit
Tree number(s): D12.776.157.530.400.875.750.960.100
D12.776.543.550.450.875.750.970.100
D12.776.543.585.400.875.750.970.100
D12.776.631.960.970.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D062547
Scope note: A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Voltage-Gated Sodium Channel Blockers
agonists:Voltage-Gated Sodium Channel Agonists
Previous Indexing: Sodium Channels (2002-2012)
Public MeSH Note: 2013
History Note: 2013
Related: Brugada Syndrome MeSH
DeCS ID: 54957
Unique ID: D062547
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/07/01
Voltage-Gated Sodium Channel beta-1 Subunit - Preferred
Concept UI M0568570
Scope note A voltage-gated sodium channel beta subunit abundantly expressed in SKELETAL MUSCLE; HEART; and BRAIN. It non-covalently associates with voltage-gated alpha subunits. Defects in the SCN1B gene, which codes for this beta subunit, are associated with generalized epilepsy with febrile seizures plus, type 1, and Brugada syndrome 5.
Preferred term Voltage-Gated Sodium Channel beta-1 Subunit
Entry term(s) SCN1B Sodium Channel beta Subunit
Voltage Gated Sodium Channel beta 1 Subunit



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