DeCS

Descriptor English:

Immunoreceptor Tyrosine-Based Inhibition Motif

Descriptor Spanish:

Motivo de Inhibición del Inmunorreceptor Basado en Tirosina

Spanish from Spain

Descriptor	motivo de inhibición de inmunorreceptores basado en tirosina
Entry term(s)	motivo ITIM motivo inhibidor de inmunorreceptores dependiente de tirosina
Scope note:	SECUENCIA DE AMINOÁCIDOS localizada en dominios intracelulares de una familia de proteínas transmembrana que regulan negativamente los procesos de transducción de señales emanados de las proteínas transmembrana que contienen MOTIVO DE ACTIVACIÓN DE INMUNORRECEPTORES BASADO EN TIROSINA. La SECUENCIA DE CONSENSO de este motivo es I(o V)LXYXXL(o V) (donde X es cualquier aminoácido). También se conoce como motivos ITIM.

Descriptor Portuguese:

Motivo de Inibição do Imunorreceptor Baseado em Tirosina

Descriptor French:

Motif d'inhibition de l'immunorécepteur dépendant de la tyrosine

Entry term(s):

Immune Receptor Tyrosine Based Inhibition Motif
Immune Receptor Tyrosine-Based Inhibition Motif
Immuno Receptor Tyrosine Based Inhibition Motif
Immuno-Receptor Tyrosine-Based Inhibition Motif
Immunoreceptor Tyrosine Based Inhibition Motif

Tree number(s):

G02.111.570.820.709.275.500.480

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D061626

Scope note:

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Public MeSH Note:

2013

History Note:

2013

DeCS ID:

55099

Unique ID:

D061626

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2013/01/01

Date of Entry:

2012/07/03

Revision Date:

2016/07/05

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Amino Acid Motifs [G02.111.570.820.709.275.500]

Amino Acid Motifs

Ankyrin Repeat [G02.111.570.820.709.275.500.030]

Ankyrin Repeat

AT-Hook Motifs [G02.111.570.820.709.275.500.050]

AT-Hook Motifs

Cystine Knot Motifs [G02.111.570.820.709.275.500.127]

Cystine Knot Motifs

F-Box Motifs [G02.111.570.820.709.275.500.205]

F-Box Motifs

Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]

Helix-Loop-Helix Motifs

Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]

Immunoreceptor Tyrosine-Based Activation Motif

Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]

Immunoreceptor Tyrosine-Based Inhibition Motif

Kazal Motifs [G02.111.570.820.709.275.500.490]

Kazal Motifs

Kelch Repeat [G02.111.570.820.709.275.500.500]

Kelch Repeat

Leucine Zippers [G02.111.570.820.709.275.500.520]

Leucine Zippers

Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]

Poly-ADP-Ribose Binding Motif

RNA-Binding Motifs [G02.111.570.820.709.275.500.869]

RNA-Binding Motifs

Sterile Alpha Motif [G02.111.570.820.709.275.500.898]

Sterile Alpha Motif

AAA Domain [G02.111.570.820.709.275.500.913]

AAA Domain

Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]

Tetratricopeptide Repeat

WD40 Repeats [G02.111.570.820.709.275.500.927]

WD40 Repeats

Zinc Fingers [G02.111.570.820.709.275.500.985]

Zinc Fingers

Immunoreceptor Tyrosine-Based Inhibition Motif - Preferred

Concept UI	M0559750
Scope note	A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.
Preferred term	Immunoreceptor Tyrosine-Based Inhibition Motif
Entry term(s)	Immune Receptor Tyrosine Based Inhibition Motif Immune Receptor Tyrosine-Based Inhibition Motif Immuno Receptor Tyrosine Based Inhibition Motif Immuno-Receptor Tyrosine-Based Inhibition Motif Immunoreceptor Tyrosine Based Inhibition Motif

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