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Descriptor English: Rho Guanine Nucleotide Exchange Factors
Descriptor Spanish: Factores de Intercambio de Guanina Nucleótido Rho
Descriptor factores Rho intercambiadores de nucleótidos de guanina
Scope note: Proteínas de señalización que funcionan como interruptores moleculares principales mediante la activación de Rho GTPasas a través de la conversión de nucleótidos de guanina. A su vez las Rho GTPasas controlan muchos aspectos del comportamiento celular mediante la regulación de múltiples vías de transducción de señales en dirección 3'.
Descriptor Portuguese: Fatores de Troca de Nucleotídeo Guanina Rho
Descriptor French: Rho guanine nucleotide exchange factors
Entry term(s): ARHGEF1
Cool 1 Protein
Cool-1 Protein
PAK Interacting Exchange Factor beta
PAK-Interacting Exchange Factor beta
PIX Protein, beta
Protein, Cool-1
Protein, beta PIX
Protein, betaPIX
Rho Guanine Nucleotide Exchange Factor (GEF) 1
Rho Guanine Nucleotide Exchange Factor 6
Rho Guanine Nucleotide Exchange Factor 7
Rho Guanine Nucleotide Exchange Factor p115
RhoGEF
RhoGEF, p115
beta PIX Protein
betaPIX Protein
p115 RhoGEF
p115RhoGEF
Tree number(s): D12.644.360.325.300.099
D12.776.476.325.300.099
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064067
Scope note: Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014; was indexed under GUANINE NUCLEOTIDE EXCHANGE FACTORS
History Note: 2014
DeCS ID: 55310
Unique ID: D064067
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2015/11/24
Rho Guanine Nucleotide Exchange Factors - Preferred
Concept UI M0579364
Scope note Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
Preferred term Rho Guanine Nucleotide Exchange Factors
Rho Guanine Nucleotide Exchange Factor p115 - Narrower
Concept UI M0065423
Preferred term Rho Guanine Nucleotide Exchange Factor p115
Entry term(s) ARHGEF1
Rho Guanine Nucleotide Exchange Factor (GEF) 1
RhoGEF
RhoGEF, p115
p115 RhoGEF
p115RhoGEF
Rho Guanine Nucleotide Exchange Factor 7 - Narrower
Concept UI M0298631
Preferred term Rho Guanine Nucleotide Exchange Factor 7
Entry term(s) Cool 1 Protein
Cool-1 Protein
PAK Interacting Exchange Factor beta
PAK-Interacting Exchange Factor beta
PIX Protein, beta
Protein, Cool-1
Protein, beta PIX
Protein, betaPIX
beta PIX Protein
betaPIX Protein
Rho Guanine Nucleotide Exchange Factor 6 - Narrower
Concept UI M0298632
Preferred term Rho Guanine Nucleotide Exchange Factor 6



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