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Descriptor English: T-Lymphoma Invasion and Metastasis-inducing Protein 1
Descriptor Spanish: Proteína 1 de Invasión e Inducción de Metástasis del Linfoma-T
Descriptor proteína 1 de invasión e inducción de metástasis del linfoma-T
Entry term(s) proteína TIAM-1
proteínaTIAM1
Scope note: Factor intercambiador de nucleótido guanina Rho que consta de dos dominios homólogos a pleckstrina flanqueando los dominios centrales de unión a Ras, homólogo a Dbl (DH) y PDZ. Estimula el intercambio GTP-GDP de las GTPasas similares a rho tales como la PROTEÍNA RAC1, la PROTEÍNA CDC42 y la PROTEÍNA RHOA, y actúa conectando señales extracelulares para la remodelación del CITOESQUELETO para la ADHESIÓN CELULAR y el MOVIMIENTO CELULAR.
Descriptor Portuguese: Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T
Descriptor French: Protéine-1 de lymphome-T induisant l'invasion et les metastases
Entry term(s): T Lymphoma Invasion and Metastasis inducing Protein 1
TIAM 1 Protein
TIAM-1 Protein
TIAM1 Protein
Tree number(s): D12.644.360.325.300.850
D12.776.476.325.300.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075684
Scope note: A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Guanine Nucleotide Exchange Factors (2007-2017)
Public MeSH Note: 2018
History Note: 2018
Related: PDZ Domains MeSH
Pleckstrin Homology Domains MeSH
DeCS ID: 57058
Unique ID: D000075684
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
T-Lymphoma Invasion and Metastasis-inducing Protein 1 - Preferred
Concept UI M000631113
Scope note A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
Preferred term T-Lymphoma Invasion and Metastasis-inducing Protein 1
Entry term(s) T Lymphoma Invasion and Metastasis inducing Protein 1
TIAM 1 Protein
TIAM-1 Protein
TIAM1 Protein



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