| Descriptor English: | Proto-Oncogene Proteins c-bcr | ||||||
| Descriptor Spanish: |
Proteínas Proto-Oncogénicas c-bcr
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| Descriptor Portuguese: | Proteínas Proto-Oncogênicas c-bcr | ||||||
| Descriptor French: | Protéines proto-oncogènes c-bcr | ||||||
| Entry term(s): |
Breakpoint Cluster Region Protein Proto Oncogene Protein bcr Proto Oncogene Protein c bcr Proto Oncogene Proteins c bcr Proto-Oncogene Protein bcr Proto-Oncogene Protein c-bcr Proto-Oncogene Proteins, bcr Proto-Oncogene Proteins, c-bcr bcr Proto Oncogene Proteins bcr Proto-Oncogene Proteins c bcr Proteins c bcr Proto Oncogene Proteins c-bcr Proteins c-bcr Proto-Oncogene Proteins c-bcr, Proto-Oncogene Protein c-bcr, Proto-Oncogene Proteins |
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| Tree number(s): |
D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.476.563.759 D12.776.624.664.700.171 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051562 | ||||||
| Scope note: | A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Public MeSH Note: | 2006; PROTO-ONCOGENE PROTEIN C-BCR was indexed under PROTEIN-TYROSINE KINASE & PROTO-ONCOGENE PROTEINS 1988-2005 |
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| History Note: | 2006(1988) |
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| DeCS ID: | 50725 | ||||||
| Unique ID: | D051562 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2016/07/05 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Proto-Oncogene Proteins c-bcr
- Preferred
| Concept UI |
M0155533 |
| Scope note | A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. |
| Preferred term | Proto-Oncogene Proteins c-bcr |
| Entry term(s) |
Breakpoint Cluster Region Protein Proto Oncogene Protein bcr Proto Oncogene Protein c bcr Proto Oncogene Proteins c bcr Proto-Oncogene Protein bcr Proto-Oncogene Protein c-bcr Proto-Oncogene Proteins, bcr Proto-Oncogene Proteins, c-bcr bcr Proto Oncogene Proteins bcr Proto-Oncogene Proteins c bcr Proteins c bcr Proto Oncogene Proteins c-bcr Proteins c-bcr Proto-Oncogene Proteins c-bcr, Proto-Oncogene Protein c-bcr, Proto-Oncogene Proteins |
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