| Descriptor English: | Solute Carrier Family 12, Member 1 | ||||||
| Descriptor Spanish: |
Miembro 1 de la Familia de Transportadores de Soluto 12
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| Descriptor Portuguese: | Membro 1 da Família 12 de Carreador de Soluto | ||||||
| Descriptor French: | Membre-1 de la famille-12 des transporteurs de solutés | ||||||
| Entry term(s): |
BSC1 Transport Protein Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2 Cotransporter, NKCC2 Cotransporter, SLC12A1 Kidney Specific Na K Cl Symporter Kidney-Specific Na-K-Cl Symporter NKCC2 Cotransporter NKCC2 Protein Na-K-Cl Symporter, Kidney-Specific Protein, BSC1 Transport Protein, NKCC2 Protein, SLC12A1 SLC12A1 Cotransporter SLC12A1 Protein Symporter, Kidney-Specific Na-K-Cl Transport Protein, BSC1 |
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| Tree number(s): |
D12.776.157.530.450.625.875.750.500 D12.776.157.530.937.750.500 D12.776.543.585.450.625.750.500 D12.776.543.585.937.875.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D064466 | ||||||
| Scope note: | Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2014; was indexed under SYMPORTER 2001-2013 |
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| History Note: | 2014 |
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| Related: |
Bartter Syndrome
MeSH | ||||||
| DeCS ID: | 55323 | ||||||
| Unique ID: | D064466 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2014/01/01 | ||||||
| Date of Entry: | 2013/07/08 | ||||||
| Revision Date: | 2015/11/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Solute Carrier Family 12, Member 1
- Preferred
| Concept UI |
M0581957 |
| Scope note | Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME. |
| Preferred term | Solute Carrier Family 12, Member 1 |
| Entry term(s) |
BSC1 Transport Protein Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2 Cotransporter, NKCC2 Cotransporter, SLC12A1 Kidney Specific Na K Cl Symporter Kidney-Specific Na-K-Cl Symporter NKCC2 Cotransporter NKCC2 Protein Na-K-Cl Symporter, Kidney-Specific Protein, BSC1 Transport Protein, NKCC2 Protein, SLC12A1 SLC12A1 Cotransporter SLC12A1 Protein Symporter, Kidney-Specific Na-K-Cl Transport Protein, BSC1 |
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