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Descriptor English: Solute Carrier Family 12, Member 4
Descriptor Spanish: Miembro 4 de la Familia de Transportadores de Soluto 12
Descriptor miembro 4 de la familia de transportadores de solutos 12
Entry term(s) miembro 4 de la familia SLC 12
Scope note: Cotransportador de K-Cl que expresa de forma ubicua, principalmente en los ERITROCITOS de la ANEMIA DE CÉLULAS FALCIFORMES. Media el cotransporte activo de potasio y cloruro a través de la membrana celular y contribuye a la homeostasis del volumen celular.
Descriptor Portuguese: Membro 4 da Família 12 de Carreador de Soluto
Descriptor French: Membre-4 de la famille-12 des transporteurs de solutés
Entry term(s): Electroneutral Potassium Chloride Cotransporter 1
Electroneutral Potassium-Chloride Cotransporter 1
Erythroid K Cl Cotransporter 1
Erythroid K-Cl Cotransporter 1
KCC1 Protein
Protein, KCC1
Protein, SLC12A4
SLC12A4 Protein
Solute Carrier Family 12 (Potassium Chloride Transporters), Member 4 Protein
Tree number(s): D12.776.157.530.450.625.750.875
D12.776.157.530.937.750.875
D12.776.543.585.450.625.750.875
D12.776.543.585.937.875.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064507
Scope note: K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasis
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2014
History Note: 2014
DeCS ID: 55325
Unique ID: D064507
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2015/11/24
Solute Carrier Family 12, Member 4 - Preferred
Concept UI M0582118
Scope note K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasis
Preferred term Solute Carrier Family 12, Member 4
Entry term(s) Electroneutral Potassium Chloride Cotransporter 1
Electroneutral Potassium-Chloride Cotransporter 1
Erythroid K Cl Cotransporter 1
Erythroid K-Cl Cotransporter 1
KCC1 Protein
Protein, KCC1
Protein, SLC12A4
SLC12A4 Protein
Solute Carrier Family 12 (Potassium Chloride Transporters), Member 4 Protein



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