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Descriptor English: Type I Secretion Systems
Descriptor Spanish: Sistemas de Secreción Tipo I
Descriptor sistemas de secreción de tipo I
Scope note: Sistemas de secreción de las bacterias Gram-negativas que traslocan efectores en un solo paso a través de las membranas internas y externas. La secreción de un solo paso se realiza mediante un canal que pasa desde el CITOPLASMA, a través de la membrana interna, el ESPACIO PERIPLASMÁTICO y la membrana externa hacia el ESPACIO EXTRACELULAR. La especificidad de los sistemas de secreción tipo 1 son determinadas mediante la especificidad de los tres subcomponentes que forman el canal - un transportador ATP (TRANSPORTADORES DE CASETE DE UNIÓN A ATP), una proteína de fusión de la membrana (PROTEÍNAS DE FUSIÓN DE LA MEMBRANA) y una proteína de la membrana externa (PROTEÍNAS DE LA MEMBRANA EXTERNA).
Descriptor Portuguese: Sistemas de Secreção Tipo I
Descriptor French: Systèmes de sécrétion de type I
Entry term(s): Bacterial Secretion Systems, Type I
Secretion System, T1SS
System, T1SS Secretion
T1SS Secretion System
Type 1 Secretion System
Type 1 Secretion Systems
Type I Secretion System
Tree number(s): D05.500.890.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069177
Scope note: Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Bacterial Secretion Systems (2010-2015)
Public MeSH Note: 2016
History Note: 2016
DeCS ID: 55945
Unique ID: D000069177
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2015/06/25
Type I Secretion Systems - Preferred
Concept UI M000604917
Scope note Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.)
Preferred term Type I Secretion Systems
Entry term(s) Bacterial Secretion Systems, Type I
Secretion System, T1SS
System, T1SS Secretion
T1SS Secretion System
Type 1 Secretion System
Type 1 Secretion Systems
Type I Secretion System



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