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Descriptor English: APOBEC-3G Deaminase
Descriptor Spanish: Desaminasa APOBEC-3G
Descriptor desaminasa APOBEC-3G
Entry term(s) citidina desaminasa relacionada con APOBEC
desaminasa APOBEC3G
enzima editora APOBEC-3G dC-dU
proteína APOBEC-3G
proteína APOBEC3G
proteína CEM15
Scope note: Desaminasa APOBEC que actúa como inhibidor de la replicación de los RETROVIRIDAE y que inhibe la movilidad de los RETROTRANSPOSONES vía mecanismos dependientes e independientes de desaminación. Es selectiva para el ADN DE CADENA SIMPLE y no desamina el ADN de cadena doble o el ARN de cadena simple o doble (ARN BICATENARIO). Exhibe una actividad antiviral potente frente al HIV-1 deficiente en PROTEÍNA VIF mediante la creación de hipermutaciones en el ADN VIRAL. También tiene actividad antiviral frente al VIRUS DE LA INMUNODEFICIENCIA DE LOS SIMIOS y el VIRUS DE LA HEPATITIS B.
Descriptor Portuguese: Desaminase APOBEC-3G
Descriptor French: APOBEC-3G Deaminase
Entry term(s): APOBEC 3G Deaminase
APOBEC 3G Protein
APOBEC 3G dC dU Editing Enzyme
APOBEC Related Cytidine Deaminase
APOBEC Related Protein
APOBEC-3G Protein
APOBEC-3G dC-dU Editing Enzyme
APOBEC-Related Cytidine Deaminase
APOBEC-Related Protein
APOBEC3G Deaminase
APOBEC3G Protein
CEM15 Protein
Cytidine Deaminase, APOBEC-Related
Deaminase, APOBEC-3G
Deaminase, APOBEC3G
Tree number(s): D08.811.277.151.486.250.500.750
D12.776.066.032
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071480
Scope note: An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.4.5
Previous Indexing: Cytidine Deaminase (2007-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56472
Unique ID: D000071480
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/06/30
APOBEC-3G Deaminase - Preferred
Concept UI M000614859
Scope note An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
Preferred term APOBEC-3G Deaminase
Entry term(s) APOBEC 3G Deaminase
APOBEC 3G Protein
APOBEC 3G dC dU Editing Enzyme
APOBEC Related Cytidine Deaminase
APOBEC Related Protein
APOBEC-3G Protein
APOBEC-3G dC-dU Editing Enzyme
APOBEC-Related Cytidine Deaminase
APOBEC-Related Protein
APOBEC3G Deaminase
APOBEC3G Protein
CEM15 Protein
Cytidine Deaminase, APOBEC-Related
Deaminase, APOBEC-3G
Deaminase, APOBEC3G



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