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Descriptor English: SAM Domain and HD Domain-Containing Protein 1
Descriptor Spanish: Proteína 1 que Contiene Dominios SAM y HD
Descriptor proteína 1 que contiene dominios SAM y HD
Entry term(s) dNTPasa SAMHD1
desoxinucleosidotrifosfato trifosfohidrolasa SAMHD1
proteína SAMHD1
Scope note: Una dNTPasa y trifosforilhidrolasa de restricción del hospedador que contiene un MOTIVO ESTÉRIL ALFA aminoterminal y un dominio central conservado de ASPARTATO e HISTIDINA (HD). Actúa sobre el ARN monocatenario dando lugar a desoxinucleósidos y trifosfato y funciona como defensa antiviral mediante su actividad dNTPasa que reduce la concentración intracelular de dNTP por debajo de la requerida para la transcripción inversa retroviral en las CÉLULAS DENDRÍTICAS y CÉLULAS MIELOIDES. También tiene actividad RIBONUCLEASA que bloquea la replicación precoz de los retrovirus como el VIH-1. Las mutaciones del gen SAMHD1 se asocian con el síndrome de Aicardi-Goutieres tipo 5 y con el LUPUS asociado con eritema pernio (chilblain) tipo 2 (CHBL2).
Descriptor Portuguese: Proteína 1 com Domínio SAM e Domínio HD
Descriptor French: Protéine-1 contenant un domaine SAM et un domaine HD
Entry term(s): SAM Domain and HD Domain Containing Protein 1
SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase
Tree number(s): D08.811.277.040.725
D08.811.277.352.700.843
D12.776.066.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076106
Scope note: A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.5.-
Previous Indexing: Monomeric GTP-Binding Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57002
Unique ID: D000076106
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
SAM Domain and HD Domain-Containing Protein 1 - Preferred
Concept UI M000632192
Scope note A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Preferred term SAM Domain and HD Domain-Containing Protein 1
Entry term(s) SAM Domain and HD Domain Containing Protein 1
SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase



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