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Descriptor English: ADAM12 Protein
Descriptor Spanish: Proteína ADAM12
Descriptor proteína ADAM12
Entry term(s) proteína 12 con dominios desintegrina y metaloproteinasa
proteína 12 que contiene los dominios desintegrina y metaloproteinasa
proteína ADAM 12
proteína ADAM-12
proteína ADAM-12-L
proteína ADAM12-S
proteína meltrina-alfa
Scope note: Proteína que tiene dominios desintegrina y metaloproteinasa y que se expresa alternativamente en dos formas distintas: una forma larga transmembranaria (ADAM12-L) y una forma corta soluble (ADAM12-S). Modula la escisión de las PROTEÍNAS DE UNIÓN A FACTOR DE CRECIMIENTO SIMILAR A INSULINA y también puede regular la FUSIÓN CELULAR durante la MIOGÉNESIS.
Descriptor Portuguese: Proteína ADAM12
Descriptor French: Protéine ADAM12
Entry term(s): ADAM 12 Protein
ADAM-12 Protein
ADAM12 L Protein
ADAM12 S Protein
ADAM12-L Protein
ADAM12-S Protein
Disintegrin and Metalloproteinase Domain Containing Protein 12
Disintegrin and Metalloproteinase Domain-Containing Protein 12
Meltrin alpha Protein
Meltrin-alpha Protein
Tree number(s): D08.811.277.656.675.374.102.125
D09.400.430.500.125
D12.776.395.033.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072199
Scope note: A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.-
Public MeSH Note: 2017; ADAM12 PROTEIN was indexed under MEMBRANE PROTEINS and ADAM PROTEINS 2006-2016; and under METALLOENDOPEPTIDASES 1997-2005
History Note: 2017 (1997)
DeCS ID: 56482
Unique ID: D000072199
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/05/27
ADAM12 Protein - Preferred
Concept UI M0272293
Scope note A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.
Preferred term ADAM12 Protein
Entry term(s) ADAM 12 Protein
ADAM-12 Protein
Disintegrin and Metalloproteinase Domain Containing Protein 12
Disintegrin and Metalloproteinase Domain-Containing Protein 12
Meltrin alpha Protein
Meltrin-alpha Protein
ADAM12-S Protein - Narrower
Concept UI M000616526
Preferred term ADAM12-S Protein
Entry term(s) ADAM12 S Protein
ADAM12-L Protein - Narrower
Concept UI M000616525
Preferred term ADAM12-L Protein
Entry term(s) ADAM12 L Protein



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