| Descriptor English: | ADAM17 Protein | ||||||
| Descriptor Spanish: |
Proteína ADAM17
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| Descriptor Portuguese: | Proteína ADAM17 | ||||||
| Descriptor French: | Protéine ADAM17 | ||||||
| Entry term(s): |
ADAM 17 Protein ADAM-17 ADAM-17 Protein Antigen, CD156b CD156b Antigen Convertase, TNF-alpha Disintegrin and Metalloproteinase Domain Containing Protein 17 Disintegrin and Metalloproteinase Domain-Containing Protein 17 TACA (Enzyme) TACE (Enzyme) TNF alpha Convertase TNF alpha Converting Enzyme TNF-alpha Convertase TNF-alpha Converting Enzyme Tumor Necrosis Factor Alpha Convertase Tumor Necrosis Factor alpha Converting Enzyme Tumor Necrosis Factor-alpha Convertase Tumor Necrosis Factor-alpha Converting Enzyme |
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| Tree number(s): |
D08.811.277.656.675.374.102.375 D09.400.430.500.375 D12.776.395.033.375 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000072198 | ||||||
| Scope note: | A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.24.86 | ||||||
| Public MeSH Note: | 2017; ADAM17 PROTEIN was indexed under ADAM PROTEINS 2005-2016, and under METALLOENDOPEPTIDASES 1996-2005 |
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| History Note: | 2017 (1996) |
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| DeCS ID: | 56484 | ||||||
| Unique ID: | D000072198 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/06 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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ADAM17 Protein
- Preferred
| Concept UI |
M0265247 |
| Scope note | A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS. |
| Preferred term | ADAM17 Protein |
| Entry term(s) |
ADAM 17 Protein ADAM-17 ADAM-17 Protein Antigen, CD156b CD156b Antigen Convertase, TNF-alpha Disintegrin and Metalloproteinase Domain Containing Protein 17 Disintegrin and Metalloproteinase Domain-Containing Protein 17 TACA (Enzyme) TACE (Enzyme) TNF alpha Convertase TNF alpha Converting Enzyme TNF-alpha Convertase TNF-alpha Converting Enzyme Tumor Necrosis Factor Alpha Convertase Tumor Necrosis Factor alpha Converting Enzyme Tumor Necrosis Factor-alpha Convertase Tumor Necrosis Factor-alpha Converting Enzyme |
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