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Descriptor English: ADAM10 Protein
Descriptor Spanish: Proteína ADAM10
Descriptor proteína ADAM10
Entry term(s) antígeno CD156c
antígeno CD156w
proteína 10 con dominios desintegrina y metaloproteinasa
proteína 10 que contiene los dominios desintegrina y metaloproteinasa
proteína ADAM-10
Scope note: Proteína que contiene dominios desintegrina y metaloproteinasa. Escinde el precursor del FACTOR DE NECROSIS TUMORAL ALFA unido a membrana entre la ALANINA 76 y la VALINA 77 dando lugar a la forma funcional del factor. También actúa sobre otras PROTEÍNAS DE LA MEMBRANA para originar sus formas solubles, entre ellas el PRECURSOR DE LA PROTEÍNA BETA AMILOIDE y las proteínas de los PRIONES.
Descriptor Portuguese: Proteína ADAM10
Descriptor French: Protéine ADAM10
Entry term(s): ADAM 10 Protein
ADAM-10 Protein
Antigen, CD156c
Antigen, CD156w
CD156c Antigen
CD156w Antigen
Disintegrin and Metalloproteinase Domain Containing Protein 10
Disintegrin and Metalloproteinase Domain-Containing Protein 10
Tree number(s): D08.811.277.656.675.374.102.250
D09.400.430.500.250
D12.776.395.033.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072197
Scope note: A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.81
Previous Indexing: ADAM Proteins (2004-2016)
Amyloid Precursor Protein Secretases (2007-2016)
Membrane Proteins (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56483
Unique ID: D000072197
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2017/05/24
ADAM10 Protein - Preferred
Concept UI M000616517
Scope note A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
Preferred term ADAM10 Protein
Entry term(s) ADAM 10 Protein
ADAM-10 Protein
Antigen, CD156c
Antigen, CD156w
CD156c Antigen
CD156w Antigen
Disintegrin and Metalloproteinase Domain Containing Protein 10
Disintegrin and Metalloproteinase Domain-Containing Protein 10



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