| Descriptor English: | ADAMTS13 Protein | ||||||
| Descriptor Spanish: |
Proteína ADAMTS13
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| Descriptor Portuguese: | Proteína ADAMTS13 | ||||||
| Descriptor French: | Protéine ADAMTS13 | ||||||
| Entry term(s): |
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein ADAMTS 13 Protein ADAMTS-13 Protein ADAMTS13 Protease vWF Cleaving Protease vWF-Cleaving Protease von Willebrand Factor Cleaving Protease von Willebrand Factor-Cleaving Protease |
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| Tree number(s): |
D08.811.277.656.675.374.102.500.813 D09.400.430.500.500.813 D12.776.395.033.500.813 D12.776.860.300.085.813 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071120 | ||||||
| Scope note: | An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.24.87 | ||||||
| Previous Indexing: |
ADAM Proteins (2006-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56487 | ||||||
| Unique ID: | D000071120 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/06 | ||||||
| Revision Date: | 2016/02/26 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Carbohydrates [D09]Carbohydrates -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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ADAMTS13 Protein
- Preferred
| Concept UI |
M000613168 |
| Scope note | An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA. |
| Preferred term | ADAMTS13 Protein |
| Entry term(s) |
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein ADAMTS 13 Protein ADAMTS-13 Protein ADAMTS13 Protease vWF Cleaving Protease vWF-Cleaving Protease von Willebrand Factor Cleaving Protease von Willebrand Factor-Cleaving Protease |
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