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Descriptor English: ADAMTS5 Protein
Descriptor Spanish: Proteína ADAMTS5
Descriptor proteína ADAMTS5
Entry term(s) agrecanasa-2
proteasa ADAMTS5
proteína ADAM con motivos de trombospondina 5
proteína ADAMTS-5
proteína ADAMTS11
Scope note: Proteasa ADAMTS que contiene dos motivos C-terminales de trombospondina (TS). Actúa principalmente como agrecanasa, escindiendo los AGRECANOS en el CARTÍLAGO, y puede estar implicada en la destrucción del agrecano en la ARTRITIS.
Descriptor Portuguese: Proteína ADAMTS5
Descriptor French: Protéine ADAMTS5
Entry term(s): A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
ADAMTS 5 Protein
ADAMTS-5 Protein
ADAMTS11 Protein
ADAMTS5 Protease
Aggrecanase 2
Aggrecanase-2
Tree number(s): D08.811.277.656.675.374.102.500.875
D09.400.430.500.500.875
D12.776.395.033.500.875
D12.776.860.300.085.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071116
Scope note: An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.24.-
Previous Indexing: ADAM Proteins (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56489
Unique ID: D000071116
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/02/26
ADAMTS5 Protein - Preferred
Concept UI M000613164
Scope note An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
Preferred term ADAMTS5 Protein
Entry term(s) A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
ADAMTS 5 Protein
ADAMTS-5 Protein
ADAMTS11 Protein
ADAMTS5 Protease
Aggrecanase 2
Aggrecanase-2



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