| Descriptor English: | Protein Deglycase DJ-1 | ||||||
| Descriptor Spanish: |
Proteína Desglicasa DJ-1
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| Descriptor Portuguese: | Proteína Desglicase DJ-1 | ||||||
| Descriptor French: | Protein deglycase DJ-1 | ||||||
| Entry term(s): |
DJ 1 PARK7 Protein DJ 1 Protein DJ-1 Protein DJ-1, Protein Deglycase DJ-1-PARK7 Protein DJ1 Protein Deglycase, Parkinsonism Associated PARK7 Protein Parkinson Protein 7 Parkinsonism Associated Deglycase |
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| Tree number(s): |
D08.811.277.785 D12.776.705.875 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071617 | ||||||
| Scope note: | A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.1.2.- | ||||||
| Previous Indexing: |
Intracellular Signaling Peptides and Proteins (1997-2016) Oncogene Proteins (1997-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56493 | ||||||
| Unique ID: | D000071617 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/04/15 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Protein Deglycase DJ-1
- Preferred
| Concept UI |
M000615251 |
| Scope note | A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE. |
| Preferred term | Protein Deglycase DJ-1 |
| Entry term(s) |
DJ 1 PARK7 Protein DJ 1 Protein DJ-1 Protein DJ-1, Protein Deglycase DJ-1-PARK7 Protein DJ1 Protein Deglycase, Parkinsonism Associated PARK7 Protein Parkinson Protein 7 Parkinsonism Associated Deglycase |
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