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Descriptor English: Protein Deglycase DJ-1
Descriptor Spanish: Proteína Desglicasa DJ-1
Descriptor proteína desglicasa DJ1
Entry term(s) Proteína de Parkinson 7
deglicasa asociada a Parkinson
deglicasa asociada a parkinsonismo
deglicasa asociada al Parkinson
desglicasa asociada a Parkinson
desglicasa asociada a parkinsonismo
desglicasa asociada al Parkinson
desglicasa asociada al parkinsonismo
proteína 7 del Parkinson
proteína DJ-1
proteína DJ-1-PARK7
proteína DJ1
proteína PARK7
proteína Parkinson 7
proteína deglicasa DJ-1
proteína del Parkinson 7
Scope note: Proteína desglicasa que repara aminoácidos y proteínas glicosiladas con metilglioxal y glioxal, liberando la proteína reparada y lactato o glicolato. Desglicosila residuos de CISTEÍNA, ARGININA y LISINA reactivando las proteínas mediante la reversión de la glicación, previniendo la formación de PRODUCTOS FINALES DE GLICACIÓN AVANZADA. Las desglicasas protegen las células frente al ESTRÉS OXIDATIVO y la MUERTE CELULAR actuando como sensores del estrés oxidativo y como CHAPERONAS MOLECULARES sensibles al potencial redox y también como PROTEASAS. Las mutaciones del gen PARK7 se asocian a la ENFERMEDAD DE PARKINSON autosómica recesiva de comienzo temprano.
Descriptor Portuguese: Proteína Desglicase DJ-1
Descriptor French: Protein deglycase DJ-1
Entry term(s): DJ 1 PARK7 Protein
DJ 1 Protein
DJ-1 Protein
DJ-1, Protein Deglycase
DJ-1-PARK7 Protein
DJ1 Protein
Deglycase, Parkinsonism Associated
PARK7 Protein
Parkinson Protein 7
Parkinsonism Associated Deglycase
Tree number(s): D08.811.277.785
D12.776.637.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071617
Scope note: A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.2.-
Previous Indexing: Intracellular Signaling Peptides and Proteins (1997-2016)
Oncogene Proteins (1997-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56493
Unique ID: D000071617
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Protein Deglycase DJ-1 - Preferred
Concept UI M000615251
Scope note A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
Preferred term Protein Deglycase DJ-1
Entry term(s) DJ 1 PARK7 Protein
DJ 1 Protein
DJ-1 Protein
DJ-1, Protein Deglycase
DJ-1-PARK7 Protein
DJ1 Protein
Deglycase, Parkinsonism Associated
PARK7 Protein
Parkinson Protein 7
Parkinsonism Associated Deglycase



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