Search
Descriptor English: High-Temperature Requirement A Serine Peptidase 2
Descriptor Spanish: Serina Peptidasa A2 que Requiere Temperaturas Altas
Descriptor Portuguese: Serina Peptidase 2 de Requerimento de Alta Temperatura A
Descriptor French: High-temperature requirement A serine peptidase 2
Entry term(s): HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease HTRA2
Serine Protease Omi
Serine Protease, Omi
Tree number(s): D08.811.277.656.300.760.431
D08.811.277.656.959.350.431
D12.644.360.075.429
D12.776.476.075.429
D12.776.575.656
D12.776.637.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074923
Scope note: A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.108
Public MeSH Note: 2018; HIGH-TEMPERATURE REQUIREMENT A SERINE PEPTIDASE 2 was indexed under SERINE ENDOPEPTIDASES and MITOCHONDRIAL PROTEINS 2000-2017
History Note: 2018 (2000)
Related: PDZ Domains MeSH
DeCS ID: 57008
Unique ID: D000074923
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05
High-Temperature Requirement A Serine Peptidase 2 - Preferred
Concept UI M000628721
Scope note A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Preferred term High-Temperature Requirement A Serine Peptidase 2
Entry term(s) HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease HTRA2
Serine Protease Omi
Serine Protease, Omi



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey