| Descriptor English: | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | ||||||
| Descriptor Spanish: |
Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina
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| Descriptor Portuguese: | Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina | ||||||
| Descriptor French: | Leucine-rich repeat serine-threonine protein kinase-2 | ||||||
| Entry term(s): |
Dardarin Protein LRRK2 Protein Leucine Rich Repeat Serine Threonine Protein Kinase 2 PARK8 Protein |
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| Tree number(s): |
D08.811.913.696.620.682.700.534 D12.776.476.563.534 D12.776.705.750 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071158 | ||||||
| Scope note: | A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.11.1 | ||||||
| Previous Indexing: |
Protein-Serine-Threonine Kinases (2005-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56511 | ||||||
| Unique ID: | D000071158 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/02/26 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Preferred
| Concept UI |
M000613241 |
| Scope note | A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8). |
| Preferred term | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 |
| Entry term(s) |
Dardarin Protein LRRK2 Protein Leucine Rich Repeat Serine Threonine Protein Kinase 2 PARK8 Protein |
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