| Descriptor English: | Suppressor of Cytokine Signaling 3 Protein | ||||||
| Descriptor Spanish: |
Proteína 3 Supresora de la Señalización de Citocinas
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| Descriptor Portuguese: | Proteína 3 Supressora da Sinalização de Citocinas | ||||||
| Descriptor French: | Protéine-3 suppressive de la signalisation des cytokine | ||||||
| Entry term(s): |
Protein, SOCS3 SOCS3 Protein Suppressor of Cytokine Signaling Protein 3 |
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| Tree number(s): |
D12.644.360.024.374.750 D12.776.157.057.249.750 D12.776.476.024.437.750 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071223 | ||||||
| Scope note: | A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Repressor Proteins (1997-2016) Suppressor of Cytokine Signaling Proteins (2006-2016) Transcription Factors (1997-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56544 | ||||||
| Unique ID: | D000071223 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/04/15 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Suppressor of Cytokine Signaling 3 Protein
- Preferred
| Concept UI |
M000613666 |
| Scope note | A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver. |
| Preferred term | Suppressor of Cytokine Signaling 3 Protein |
| Entry term(s) |
Protein, SOCS3 SOCS3 Protein Suppressor of Cytokine Signaling Protein 3 |
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