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Descriptor English: Suppressor of Cytokine Signaling Proteins
Descriptor Spanish: Proteínas Supresoras de la Señalización de Citocinas
Descriptor Portuguese: Proteínas Supressoras da Sinalização de Citocina
Descriptor French: Protéines SOCS
Entry term(s): SOCS Proteins
Suppressors of Cytokine Signaling Proteins
Tree number(s): D12.644.360.024.374
D12.776.157.057.249
D12.776.476.024.437
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050826
Scope note: A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006
History Note: 2006
DeCS ID: 50800
Unique ID: D050826
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/24
Suppressor of Cytokine Signaling Proteins - Preferred
Concept UI M0478075
Scope note A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.
Preferred term Suppressor of Cytokine Signaling Proteins
Entry term(s) SOCS Proteins
Suppressors of Cytokine Signaling Proteins



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