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Descriptor English: ATP Binding Cassette Transporter, Subfamily G, Member 2
Descriptor Spanish: Transportador de Casetes de Unión a ATP, Subfamilia G, Miembro 2
Descriptor transportador de casetes de unión a ATP, subfamilia G, miembro 2
Entry term(s) antígeno CD338
proteína ABCG2
transportador ABCG2
Scope note: Proteína transportadora de casetes de unión a ATP, de la subfamilia de proteínas G, que funciona como exportador de UREA de alta capacidad, transportador de ESTEROLES y participa en la absorción y expulsión de muchos fármacos. Su actividad de expulsión de AGENTES ANTINEOPLÁSICOS contribuye a la RESISTENCIA FARMACOLÓGICA. Funciona como homodímero y se expresa en células de diversos órganos, así como en CÉLULAS MADRE NEOPLÁSICAS.
Descriptor Portuguese: Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP
Descriptor French: Membre-2 de la sous-famille G des transporteurs à cassette liant l'ATP
Entry term(s): ABCG2 Protein
ABCG2 Transporter
ATP Binding Cassette Transporter, Sub-Family G, Member 2
CD338 Antigen
Tree number(s): D09.400.430.890.020.457.500
D12.776.157.530.100.228.500
D12.776.395.550.020.457.500
D12.776.543.550.192.457.500
D12.776.543.585.100.228.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000070997
Scope note: ATP-binding cassette transporter, sub-family G protein that functions as a high capacity UREA exporter, transporter of STEROLS, and in the absorption and efflux of many drugs. Its efflux activity for ANTINEOPLASTIC AGENTS contributes to DRUG RESISTANCE. It functions as a homodimer and is expressed by cells in a variety of organs, as well as by NEOPLASTIC STEM CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: ATP-Binding Cassette Transporters (1999-2016)
Public MeSH Note: 2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY G, MEMBER 2 2017-2018
History Note: 2019 (2017)
DeCS ID: 56579
Unique ID: D000070997
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2018/02/28
ATP Binding Cassette Transporter, Subfamily G, Member 2 - Preferred
Concept UI M000612844
Scope note ATP-binding cassette transporter, sub-family G protein that functions as a high capacity UREA exporter, transporter of STEROLS, and in the absorption and efflux of many drugs. Its efflux activity for ANTINEOPLASTIC AGENTS contributes to DRUG RESISTANCE. It functions as a homodimer and is expressed by cells in a variety of organs, as well as by NEOPLASTIC STEM CELLS.
Preferred term ATP Binding Cassette Transporter, Subfamily G, Member 2
Entry term(s) ABCG2 Protein
ABCG2 Transporter
ATP Binding Cassette Transporter, Sub-Family G, Member 2
CD338 Antigen



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