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Descriptor English: Calcium Release Activated Calcium Channels
Descriptor Spanish: Canales de Calcio Activados por la Liberación de Calcio
Descriptor canales de calcio activados por liberación de calcio
Entry term(s) canal CRAC
canal de calcio activado por liberación de calcio
canales CRAC
canales de calcio activados por la liberación de calcio
Scope note: Canales de calcio especializados que se localizan en el RETÍCULO ENDOPLÁSMICO y la MEMBRANA PLASMÁTICA. Contienen la subunidad de poro PROTEÍNA ORAI1, que se activa mediante las MOLÉCULAS DE INTERACCIÓN ESTROMAL tras el agotamiento del calcio intracelular.
Descriptor Portuguese: Canais de Cálcio Ativados pela Liberação de Cálcio
Descriptor French: Canaux calciques activés par la libération de calcium
Entry term(s): CRAC Channel
CRAC Channels
Calcium Release Activated Calcium Channel
Calcium Release Activated Channels
Calcium Release-Activated Calcium Channels
Calcium Release-Activated Channels
Channel, CRAC
Tree number(s): D12.776.157.530.400.150.740
D12.776.543.550.450.150.740
D12.776.543.585.400.150.740
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071739
Scope note: Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Calcium Channels (1995-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56582
Unique ID: D000071739
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27
Calcium Release Activated Calcium Channels - Preferred
Concept UI M000615422
Scope note Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion.
Preferred term Calcium Release Activated Calcium Channels
Entry term(s) CRAC Channel
CRAC Channels
Calcium Release Activated Calcium Channel
Calcium Release Activated Channels
Calcium Release-Activated Calcium Channels
Calcium Release-Activated Channels
Channel, CRAC



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