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Descriptor English: Forkhead Box Protein O3
Descriptor Spanish: Proteína Forkhead Box O3
Descriptor proteína forkhead box O3
Entry term(s) proteína 1 similar a forkhead en el rabdomiosarcoma
proteína FOXO3
Scope note: Factor de transcripción "forkhead box" y activador transcripcional que desencadena la muerte celular programada (APOPTOSIS) de tipo 1 en ausencia de PROTEÍNAS INHIBIDORAS DE LA APOPTOSIS, incluida la muerte celular neuronal inducida por el ESTRÉS OXIDATIVO. Reconoce y se une a la secuencia de ADN 5'-(AG)TAAA(TC)A-3' y está implicado en la regulación postranscripcional del PROTOONCOGÉN c-MYC.
Descriptor Portuguese: Proteína Forkhead Box O3
Descriptor French: Protéine O3 à motif en tête de fourche
Entry term(s): FOXO3 Protein
Forkhead in Rhabdomyosarcoma Like 1 Protein
Forkhead in Rhabdomyosarcoma-Like 1 Protein
Protein, FOXO3
Tree number(s): D12.776.260.950.249.125
D12.776.930.977.249.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071316
Scope note: A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Forkhead Transcription Factors (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56615
Unique ID: D000071316
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Forkhead Box Protein O3 - Preferred
Concept UI M000614016
Scope note A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.
Preferred term Forkhead Box Protein O3
Entry term(s) FOXO3 Protein
Forkhead in Rhabdomyosarcoma Like 1 Protein
Forkhead in Rhabdomyosarcoma-Like 1 Protein
Protein, FOXO3



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