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Descriptor English: Ubiquitin-Specific Peptidase 7
Descriptor Spanish: Peptidasa Específica de Ubiquitina 7
Descriptor peptidasa específica de ubiquitina 7
Entry term(s) peptidasa ubiquitin-específica asociada al virus del herpes
proteína HAUSP
proteína USP7
Scope note: Es una ubiquitinilhidrolasa que desubiquitina algunas proteínas con papeles críticos en la REPARACIÓN DEL ADN, el crecimiento y la supervivencia celular, incluidas la PROTEÍNA SUPRESORA DE TUMORES P53, las PROTEÍNAS MDM2 y la FOSFOHIDROLASA PTEN. Asimismo, estabiliza la proteína transcripcional transactivadora VMW110 durante la infección por el VHS-1, con lo que contribuye a su función como FACTOR TRANSACTOR NUCLEAR.
Descriptor Portuguese: Peptidase 7 Específica de Ubiquitina
Descriptor French: Ubiquitin-specific peptidase 7
Entry term(s): HAUSP Protein
Herpesvirus Associated Ubiquitin Specific Peptidase
Herpesvirus-Associated Ubiquitin-Specific Peptidase
Peptidase 7, Ubiquitin-Specific
Peptidase, Herpesvirus-Associated Ubiquitin-Specific
USP7 Protein
Ubiquitin Specific Peptidase 7
Ubiquitin-Specific Peptidase, Herpesvirus-Associated
Tree number(s): D08.811.037.750.750
D08.811.277.656.300.887.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076084
Scope note: A ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.19.12
Previous Indexing: Endopeptidases (2002-2017)
Ubiquitin Thiolesterase (2008-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 56990
Unique ID: D000076084
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Ubiquitin-Specific Peptidase 7 - Preferred
Concept UI M000632175
Scope note A ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.
Preferred term Ubiquitin-Specific Peptidase 7
Entry term(s) HAUSP Protein
Herpesvirus Associated Ubiquitin Specific Peptidase
Herpesvirus-Associated Ubiquitin-Specific Peptidase
Peptidase 7, Ubiquitin-Specific
Peptidase, Herpesvirus-Associated Ubiquitin-Specific
USP7 Protein
Ubiquitin Specific Peptidase 7
Ubiquitin-Specific Peptidase, Herpesvirus-Associated



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