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Descriptor English: Tumor Necrosis Factor alpha-Induced Protein 3
Descriptor Spanish: Proteína 3 Inducida por el Factor de Necrosis Tumoral alfa
Descriptor proteína 3 inducida por el factor de necrosis tumoral alfa
Entry term(s) proteína TNFAIP3
proteína con motivos en dedo de zinc A20
Scope note: Enzima editora de la UBICUITINA que funciona tanto como ubicuitina ligasa como desubicuitinasa. Contiene varios DEDOS DE ZINC y actúa en la respuesta inmunitaria y en la INFLAMACIÓN modulando las señales del TNF-ALFA, la IL1-BETA o de patógenos vía RECEPTORES TIPO TOLL parando la actividad de NF-KAPPA B.
Descriptor Portuguese: Proteína 3 Induzida por Fator de Necrose Tumoral alfa
Descriptor French: Protéine-3 induite par le facteur de nécrose tumorale alpha
Entry term(s): TNFAIP3 Protein
Tumor Necrosis Factor alpha Induced Protein 3
Zinc Finger Protein A20
Tree number(s): D08.811.037.750.500
D08.811.277.656.300.887.750
D08.811.464.938.750.813
D12.644.360.950
D12.776.476.938
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072598
Scope note: A UBIQUITIN editing enzyme that functions as both a ubiquitin ligase and deubiquitinase. It contains several ZINC FINGERS and functions in the immune response and INFLAMMATION by modulating signals from TNF-ALPHA; IL1-BETA; or pathogens via TOLL-LIKE RECEPTORS to terminate NF-KAPPA B activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.19.12
Previous Indexing: Cysteine Endopeptidases (2006-2016)
DNA-Binding Proteins (2006-2016)
Intracellular Signaling Peptides and Proteins (2006-2016)
Nuclear Proteins (1992-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56457
Unique ID: D000072598
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01
Tumor Necrosis Factor alpha-Induced Protein 3 - Preferred
Concept UI M000617434
Scope note A UBIQUITIN editing enzyme that functions as both a ubiquitin ligase and deubiquitinase. It contains several ZINC FINGERS and functions in the immune response and INFLAMMATION by modulating signals from TNF-ALPHA; IL1-BETA; or pathogens via TOLL-LIKE RECEPTORS to terminate NF-KAPPA B activity.
Preferred term Tumor Necrosis Factor alpha-Induced Protein 3
Entry term(s) TNFAIP3 Protein
Tumor Necrosis Factor alpha Induced Protein 3
Zinc Finger Protein A20



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