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Descriptor English: ATP Binding Cassette Transporter, Subfamily A
Descriptor Spanish: Subfamilia A de Transportadores de Casete de Unión al ATP
Descriptor transportadores de casetes de unión al ATP, subfamilia A
Entry term(s) transportadores ABCA
Scope note: Amplia subfamilia, muy conservada, de transportadores de casetes de unión a ATP caracterizada estructuralmente por un dominio transmembranario constituido por seis HÉLICES ALFA, una gran asa extracelular, un dominio de unión a nucleótidos y una secuencia citoplasmática conservada de 80 aminoácidos. En los seres humanos, incluye de ABCA1 (TRANSPORTADOR DE CASETES DE UNIÓN A ATP 1) a ABCA10, y también a ABCA12 y ABCA13.
Descriptor Portuguese: Subfamília A de Transportador de Cassetes de Ligação de ATP
Descriptor French: Sous-famille A de transporteurs à cassette liant l'ATP
Entry term(s): ABCA Transporters
ATP Binding Cassette Transporter, Sub Family A
ATP Binding Cassette Transporter, Sub-Family A
Transporters, ABCA
Tree number(s): D09.400.430.890.020.381
D12.776.157.530.100.050
D12.776.395.550.020.381
D12.776.543.550.192.381
D12.776.543.585.100.190
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073874
Scope note: A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: ATP-Binding Cassette Transporters (2001-2017)
Public MeSH Note: 2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY A 2018
History Note: 2019 (2018)
DeCS ID: 57072
Unique ID: D000073874
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2018/02/28
ATP Binding Cassette Transporter, Subfamily A - Preferred
Concept UI M000624144
Scope note A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.
Preferred term ATP Binding Cassette Transporter, Subfamily A
Entry term(s) ABCA Transporters
ATP Binding Cassette Transporter, Sub Family A
ATP Binding Cassette Transporter, Sub-Family A
Transporters, ABCA



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