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Descriptor English: Promyelocytic Leukemia Zinc Finger Protein
Descriptor Spanish: Proteína de la Leucemia Promielocítica con Dedos de Zinc
Descriptor proteína de la leucemia promielocítica con dedos de zinc
Entry term(s) proteína PLZF
proteína ZBTB16
Scope note: Factor de transcripción de tipo Kruppel que consta de un DOMINIO BTB N-terminal y nueve DEDOS DE ZINC CYS2-HIS2. Se localiza en el núcleo y regula la progresión del ciclo celular y la expresión génica para el desarrollo y homeostasis de los tejidos; también puede funcionar como regulador epigenético mediante su interacción con las HISTONA DESACETILASAS. Los reordenamientos génicos que implican al gen ZBTB16 se asocian a la LEUCEMIA PROMIELOCÍTICA AGUDA.
Descriptor Portuguese: Proteína com Dedos de Zinco da Leucemia Promielocítica
Descriptor French: Protéine à doigts de zinc de la leucémie promyélocytaire
Entry term(s): PLZF Protein
Promyelocytic Leukaemia Zinc Finger Protein
ZBTB16 Protein
Zinc Finger and BTB Domain Containing 16 Protein
Tree number(s): D12.776.260.522.625
D12.776.930.375.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075722
Scope note: A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Kruppel-Like Transcription Factors (1995-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57115
Unique ID: D000075722
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2018/05/21
Promyelocytic Leukemia Zinc Finger Protein - Preferred
Concept UI M000631303
Scope note A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
Preferred term Promyelocytic Leukemia Zinc Finger Protein
Entry term(s) PLZF Protein
Promyelocytic Leukaemia Zinc Finger Protein
ZBTB16 Protein
Zinc Finger and BTB Domain Containing 16 Protein



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