| Descriptor English: | Zinc Finger Protein Gli3 | ||||||
| Descriptor Spanish: |
Proteína Gli3 con Dedos de Zinc
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| Descriptor Portuguese: | Proteína Gli3 com Dedos de Zinco | ||||||
| Descriptor French: | Protéine à doigts de zinc Gli3 | ||||||
| Entry term(s): |
GLI Kruppel Family Member 3 Protein GLI-Kruppel Family Member 3 Protein Glioma Associated Oncogene Family Zinc Finger 3 Protein Glioma-Associated Oncogene Family Zinc Finger 3 Protein |
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| Tree number(s): |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074290 | ||||||
| Scope note: | A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
DNA-Binding Proteins (1990-2017) Kruppel-Like Transcription Factors (2006-2017) Nerve Tissue Proteins (2006-2017) Transcription Factors (1990-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57117 | ||||||
| Unique ID: | D000074290 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/02/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Zinc Finger Protein Gli3
- Preferred
| Concept UI |
M000625941 |
| Scope note | A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES. |
| Preferred term | Zinc Finger Protein Gli3 |
| Entry term(s) |
GLI Kruppel Family Member 3 Protein GLI-Kruppel Family Member 3 Protein Glioma Associated Oncogene Family Zinc Finger 3 Protein Glioma-Associated Oncogene Family Zinc Finger 3 Protein |
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