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Descriptor English: Doripenem
Descriptor Spanish: Doripenem
Descriptor doripenem
Entry term(s) S 4661
S-4661
S4661
ácido 2-(5-sulfamoilaminometilpirrolidin-3-iltio)-6-(1-hidroxietil)-1-metilcarbapen-2-em-3-carboxílico
Scope note: Antibacteriano derivado carbapenémico que es más estable con respecto a la deshidropeptidasa I renal que el IMIPENEM, pero que no necesita administrarse con un inhibidor de la enzima como la CILASTATINA. Se usa en el tratamiento de infecciones tales como la NEUMONÍA ADQUIRIDA EN EL HOSPITAL y de infecciones intraabdominales o urinarias complicadas tales como la PIELONEFRITIS.
Descriptor Portuguese: Doripenem
Descriptor French: Doripénem
Entry term(s): 2-(5-sulfamoylaminomethylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid
S 4661
S-4661
S4661
Tree number(s): D02.065.589.099.124.150
D03.633.100.300.124.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077726
Scope note: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Registry Number: BHV525JOBH
CAS Type 1 Name: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((aminosulfonyl)amino)methyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-, (4R,5S,6S)-
Public MeSH Note: 2019; DORIPENEM was indexed under CARBAPENEMS 1996-2018
History Note: 2019 (1996)
DeCS ID: 57733
Unique ID: D000077726
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/10
Doripenem - Preferred
Concept UI M0260551
Scope note A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Preferred term Doripenem
2-(5-sulfamoylaminomethylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid - Narrower
Concept UI M000641382
Preferred term 2-(5-sulfamoylaminomethylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid
S 4661 - Narrower
Concept UI M0472565
Preferred term S 4661
Entry term(s) S-4661
S4661



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