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Descriptor English: Thienamycins
Descriptor Spanish: Tienamicinas
Descriptor tienamicinas
Entry term(s) antibióticos tienamicinas
Scope note: Antibióticos betalactámicos que difieren de las PENICILINAS en que el átomo de azufre de la tiazolidina está sustituido por un carbono siendo, por tanto, el azufre el primer átomo en la cadena lateral. Son químicamente inestables, pero tienen un espectro antibacteriano muy amplio. La tienamicina y sus derivados más estables están propuestos para ser utilizados en combinación con inhibidores enzimáticos.
Descriptor Portuguese: Tienamicinas
Descriptor French: Thiénamycine
Entry term(s): Antibiotics, Thienamycin
Thienamycin Antibiotics
Tree number(s): D02.065.589.099.124.300
D03.633.100.300.124.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013845
Scope note: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Previous Indexing: Amides (1966-1973)
Antibiotics (1966-1982)
Lactams (1974-1982)
Public MeSH Note: 83
History Note: 83
DeCS ID: 27855
Unique ID: D013845
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/05/05
Revision Date: 2016/06/01
Thienamycins - Preferred
Concept UI M0021334
Scope note Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Preferred term Thienamycins
Entry term(s) Antibiotics, Thienamycin
Thienamycin Antibiotics



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