| Descriptor English: | Cilastatin, Imipenem Drug Combination | ||||||
| Descriptor Spanish: |
Combinación Cilastatina e Imipenem
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| Descriptor Portuguese: | Combinação Imipenem e Cilastatina | ||||||
| Descriptor French: | Association d'imipénem et de cilastatine | ||||||
| Entry term(s): |
Cilastatin, Imipenem Imipenem - Cilastatin Imipenem - Cilastatin Sodium Imipenem Cilastatin Imipenem Cilastatin Sodium Imipenem Cilastatin, Sodium Salt Imipenem-Cilastatin Imipenem-Cilastatin Sodium Imipenem-Cilastatin, Sodium Salt MK 0787 MK 0791 mixture MK 0787-MK 0791 mixture MK 787 MK 791 mixture MK 787-MK 791 mixture Primaxin Thienam Tienam 500 Zienam |
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| Tree number(s): |
D02.065.589.099.124.300.500.500 D02.455.426.392.368.533.200.500 D03.633.100.300.124.300.500.500 D10.251.355.325.200.500 D26.310.356 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000077728 | ||||||
| Scope note: | Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Anti-Bacterial Agents Protease Inhibitors |
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| Registry Number: | 92309-29-0 | ||||||
| Public MeSH Note: | 2019; CILASTATIN, IMIPENEM DRUG COMBINATION was indexed under CILASTATIN and IMIPENEM 1995-2018 and 1988-1994; under DRUG COMBINATIONS 1995-2018 and 1985-1994; and under CYCLOPROPANES and THIENAMYCINS 1985-1988 |
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| History Note: | 2019 (1985) |
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| DeCS ID: | 57735 | ||||||
| Unique ID: | D000077728 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2019/01/01 | ||||||
| Date of Entry: | 2018/07/09 | ||||||
| Revision Date: | 2018/04/10 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds -
CHEMICALS AND DRUGS
Lipids [D10]Lipids -
CHEMICALS AND DRUGS
Pharmaceutical Preparations [D26]Pharmaceutical Preparations
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Cilastatin, Imipenem Drug Combination
- Preferred
Thienam
- Narrower
Tienam 500
- Narrower
Primaxin
- Narrower
MK 0787-MK 0791 mixture
- Narrower
Zienam
- Narrower
Imipenem-Cilastatin, Sodium Salt
- Narrower
| Concept UI |
M0130282 |
| Scope note | Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. |
| Preferred term | Cilastatin, Imipenem Drug Combination |
| Entry term(s) |
Cilastatin, Imipenem Imipenem - Cilastatin Imipenem Cilastatin Imipenem-Cilastatin |
| Concept UI |
M0130280 |
| Preferred term | Thienam |
| Concept UI |
M0130281 |
| Preferred term | Tienam 500 |
| Concept UI |
M0130278 |
| Preferred term | Primaxin |
| Concept UI |
M0130276 |
| Preferred term | MK 0787-MK 0791 mixture |
| Entry term(s) |
MK 0787 MK 0791 mixture MK 787 MK 791 mixture MK 787-MK 791 mixture |
| Concept UI |
M0130279 |
| Preferred term | Zienam |
| Concept UI |
M0322079 |
| Preferred term | Imipenem-Cilastatin, Sodium Salt |
| Entry term(s) |
Imipenem - Cilastatin Sodium Imipenem Cilastatin Sodium Imipenem Cilastatin, Sodium Salt Imipenem-Cilastatin Sodium |
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