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Descriptor English: Imipenem
Descriptor Spanish: Imipenem
Descriptor imipenem
Entry term(s) N-formimidoiltienamicina
imipemida
Scope note: Tienamicina semisintética con amplio espectro de actividad antibacteriana frente a bacterias grampositivas y gramnegativas, aerobias y anaerobias, incluyendo cepas multirresistentes. Es estable frente a las betalactamasas. Estudios clínicos han demostrado alta eficacia en el tratamiento de infecciones de diversos sistemas corporales. Su efectividad se incrementa cuando se administra en combinación con CILASTATINA, un inhibidor de la dipeptidasa renal.
Descriptor Portuguese: Imipenem
Descriptor French: Imipénem
Entry term(s): Anhydrous Imipenem
Anhydrous, Imipenem
Imipemide
Imipenem Anhydrous
Imipenem, Anhydrous
MK 0787
MK-0787
MK0787
N Formimidoylthienamycin
N-Formimidoylthienamycin
Tree number(s): D02.065.589.099.124.300.500
D03.633.100.300.124.300.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015378
Scope note: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Registry Number: 71OTZ9ZE0A
CAS Type 1 Name: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
Previous Indexing: Antibiotics (1980-1982)
Thienamycins (1983-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 28157
Unique ID: D015378
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/06/03
Revision Date: 2016/05/31
Imipenem - Preferred
Concept UI M0023689
Scope note Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Preferred term Imipenem
Entry term(s) Imipemide
N Formimidoylthienamycin
N-Formimidoylthienamycin
Imipenem, Anhydrous - Narrower
Concept UI M0329530
Preferred term Imipenem, Anhydrous
Entry term(s) Anhydrous Imipenem
Anhydrous, Imipenem
Imipenem Anhydrous
MK-0787 - Narrower
Concept UI M0351093
Preferred term MK-0787
Entry term(s) MK 0787
MK0787



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