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Descriptor English: Meropenem
Descriptor Spanish: Meropenem
Descriptor meropenem
Entry term(s) SM 7338
SM-7338
SM7338
merrem
penem
ronem
ácido 3-(5-dimetilcarbamoilpirrolidin-3-iltio)-6-(1-hidroxietil)-4-metil-7-oxo-1-azabiciclo(3.2.0)hepta-2-eno-2-carboxílico
Scope note: Antibacteriano derivado de la tienamicina que es más estable con respecto a la deshidropeptidasa I renal que el IMIPENEM, pero que no necesita administrarse con un inhibidor de la enzima como la CILASTATINA. Se usa en el tratamiento de infecciones bacterianas, tales como las infecciones en pacientes inmunodeprimidos.
Descriptor Portuguese: Meropeném
Descriptor French: Méropénème
Entry term(s): 3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
Merrem
Penem
Ronem
SM 7338
SM-7338
SM7338
Tree number(s): D02.065.589.099.124.300.750
D03.633.100.300.124.300.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077731
Scope note: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Registry Number: FV9J3JU8B1
CAS Type 1 Name: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-((dimethylamino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(3S*,5S*),4alpha,5beta,6beta(R*)))-
Public MeSH Note: 2019; MEROPENEM was indexed under THIENAMYCINS 1989-2018
History Note: 2019 (1989)
DeCS ID: 57736
Unique ID: D000077731
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/10
Meropenem - Preferred
Concept UI M0165499
Scope note A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.
Preferred term Meropenem
3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid - Broader
Concept UI M000641389
Preferred term 3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
Merrem - Narrower
Concept UI M0165496
Preferred term Merrem
Ronem - Narrower
Concept UI M0537236
Preferred term Ronem
Penem - Narrower
Concept UI M0574425
Preferred term Penem
SM 7338 - Narrower
Concept UI M0165497
Preferred term SM 7338
Entry term(s) SM-7338
SM7338



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