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Descriptor English: Amifampridine
Descriptor Spanish: Amifampridina
Descriptor Portuguese: Amifampridina
Descriptor French: Amifampridine
Entry term(s): 3,4 Diaminopyridine
3,4-Diaminopyridine
Amifampridine Phosphate
Firdapse
Ruzurgi
Tree number(s): D02.092.080.060.500
D03.383.725.050.060.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077770
Scope note: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Neuromuscular Agents
Potassium Channel Blockers
Registry Number: RU4S6E2G0J
CAS Type 1 Name: 3,4-Pyridinediamine
Public MeSH Note: 2019; see 3,4-DIAMINOPYRIDINE 1978-2018; AMIFAMPRIDINE was indexed under 4-AMINOPYRIDINE/analogs & derivatives 1990-2018; under AMINOPYRIDINES 1978-1989; and under PYRIDINES 1978-1979
History Note: 2019 (1978)
DeCS ID: 57749
Unique ID: D000077770
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05
Amifampridine - Preferred
Concept UI M0066295
Scope note 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Preferred term Amifampridine
Entry term(s) 3,4 Diaminopyridine
3,4-Diaminopyridine
Firdapse - Narrower
Concept UI M000621460
Preferred term Firdapse
Amifampridine Phosphate - Narrower
Concept UI M000621461
Preferred term Amifampridine Phosphate
Ruzurgi - Narrower
Concept UI M000649445
Preferred term Ruzurgi



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