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Descriptor English: Glutamate-Cysteine Ligase
Descriptor Spanish: Glutamato-Cisteína Ligasa
Descriptor glutamato-cisteína ligasa
Entry term(s) gamma glutamil-cisteína sintetasa
gamma-glutamil-cisteína sintetasa
gammaglutamil-cisteína sintetasa
gammaglutamilcisteína sintetasa
Scope note: Una de las enzimas activas en el ciclo del gamma-glutamilo. Cataliza la síntesis de gamma-glutamilcisteína a partir de glutamato y cisteína, en presencia de ATP, con formación de ADP y ortofosfato. EC 6.3.2.2.
Descriptor Portuguese: Glutamato-Cisteína Ligase
Descriptor French: Glutamate-cysteine ligase
Entry term(s): Glutamate Cysteine Ligase
Glutamylcysteine Synthetase
Ligase, Glutamate-Cysteine
Synthetase, Glutamylcysteine
Synthetase, gamma-Glutamyl-Cysteine
gamma Glutamyl Cysteine Synthetase
gamma-Glutamyl-Cysteine Synthetase
Tree number(s): D08.811.464.259.850.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005721
Scope note: One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.3.2.2
CAS Type 1 Name: L-Glutamate:L-cysteine gamma-ligase (ADP-forming)
Previous Indexing: Cysteine (1973-1976)
Glutamates (1973-1976)
Peptide Synthetases (1973-1976)
Public MeSH Note: 98; see GAMMA-GLUTAMYL-CYSTEINE SYNTHETASE 1991-97; see PEPTIDE SYNTHETASES 1977-90
History Note: 98(77)
DeCS ID: 5860
Unique ID: D005721
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1976/05/19
Revision Date: 2003/07/09
Glutamate-Cysteine Ligase - Preferred
Concept UI M0008975
Scope note One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Preferred term Glutamate-Cysteine Ligase
Entry term(s) Glutamate Cysteine Ligase
Glutamylcysteine Synthetase
Ligase, Glutamate-Cysteine
Synthetase, Glutamylcysteine
Synthetase, gamma-Glutamyl-Cysteine
gamma Glutamyl Cysteine Synthetase
gamma-Glutamyl-Cysteine Synthetase



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