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Descriptor English: Amiloride
Descriptor Spanish: Amilorida
Descriptor amilorida
Entry term(s) amiloride
Scope note: Compueto de piracina que inhibe la reabsorción de SODIO a través de los CANALES DE SODIO en las CÉLULAS EPITELIALES renales. Dicha inhibición crea un potencial negativo en las membranas luminales de las células principales, localizadas en la porción distal del túbulo contorneado y el tubo colector. El potencial negativo reduce la secrecion de iones potasio e hidrógeno. La amilorida se utiliza asociada a DIURÉTICOS para evitar la pérdida de POTASIO. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Descriptor Portuguese: Amilorida
Descriptor French: Amiloride
Entry term(s): Chlorhydrate d'amiloride
Chlorhydrate d'amiloride anhydre
Tree number(s): D03.383.679.149
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000584
Scope note: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Diuretics
Acid Sensing Ion Channel Blockers
Epithelial Sodium Channel Blockers
Registry Number: 7DZO8EB0Z3
CAS Type 1 Name: Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
DeCS ID: 588
Unique ID: D000584
NLM Classification: QV 160
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Amiloride - Preferred
Concept UI M0000906
Preferred term Amiloride
Chlorhydrate d'amiloride anhydre - Narrower
Concept UI M0330757
Preferred term Chlorhydrate d'amiloride anhydre
Chlorhydrate d'amiloride - Narrower
Concept UI M0330756
Preferred term Chlorhydrate d'amiloride



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