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Descriptor English: | Amiloride | ||||||
Descriptor Spanish: |
Amilorida
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Descriptor Portuguese: | Amilorida | ||||||
Descriptor French: | Amiloride | ||||||
Entry term(s): |
Chlorhydrate d'amiloride Chlorhydrate d'amiloride anhydre |
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Tree number(s): |
D03.383.679.149 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000584 | ||||||
Scope note: | A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) |
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Allowable Qualifiers: |
AA analogues et dérivés AD administration et posologie AE effets indésirables AG agonistes AI antagonistes et inhibiteurs AN analyse BL sang CF liquide cérébrospinal CH composition chimique CL classification CS synthèse chimique EC économie HI histoire IM immunologie IP isolement et purification ME métabolisme PD pharmacologie PK pharmacocinétique PO intoxication RE effets des radiations SD ressources et distribution ST normes TO toxicité TU usage thérapeutique UR urine |
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Pharm Action: |
Diuretics Acid Sensing Ion Channel Blockers Epithelial Sodium Channel Blockers |
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Registry Number: | 7DZO8EB0Z3 | ||||||
CAS Type 1 Name: | Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro- | ||||||
DeCS ID: | 588 | ||||||
Unique ID: | D000584 | ||||||
NLM Classification: | QV 160 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 1986/01/01 | ||||||
Date of Entry: | 1999/01/01 | ||||||
Revision Date: | 2017/05/24 |
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PRODUITS CHIMIQUES ET PHARMACEUTIQUES
Composés hétérocycliques [D03]Composés hétérocycliques
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Amiloride
- Preferred
Chlorhydrate d'amiloride anhydre
- Narrower
Chlorhydrate d'amiloride
- Narrower
Concept UI |
M0000906 |
Preferred term | Amiloride |
Concept UI |
M0330757 |
Preferred term | Chlorhydrate d'amiloride anhydre |
Concept UI |
M0330756 |
Preferred term | Chlorhydrate d'amiloride |
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