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Descriptor English: Calicheamicins
Descriptor Spanish: Calicheamicinas
Descriptor calicheamicinas
Entry term(s) calicheamicina
Scope note: Aminoglucósidos enediínicos derivados de la bacteria MICROMONOSPORA ECHINOSPORA que se utilizan como antibióticos antineoplásicos. Se unen al ADN en células tanto sanas como tumorales, causando la escisión de las cadenas y la muerte celular.
Descriptor Portuguese: Calicheamicinas
Descriptor French: Calicheamicines
Entry term(s): Calicheamicin
Tree number(s): D02.455.326.271.244.250
D02.455.326.397.680.500.500.250
D09.408.051.247
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000080084
Scope note: Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Previous Indexing: Aminoglycosides (1989-2019)
Enediynes (2007-2019)
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59044
Unique ID: D000080084
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/02/25
Calicheamicins - Preferred
Concept UI M000646417
Scope note Enediyne aminoglycosides derived from the bacterium MICROMONOSPORA ECHINOSPORA that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and cell death.
Preferred term Calicheamicins
Calicheamicin - Narrower
Concept UI M000646418
Preferred term Calicheamicin



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