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Descriptor English: Chaperone-Mediated Autophagy
Descriptor Spanish: Autofagia Mediada por Chaperones
Descriptor autofagia mediada por chaperonas
Scope note: Tipo selectivo de autofagia en el que un conjunto específico de proteínas citosólicas es desplazado a través de la membrana de los LISOSOMAS mediante translocación de proteínas, en lugar de mediante invaginación de la membrana lisosómica. Las proteínas que se degradarán por autofagia mediada por chaperonas (AMC) contienen un motivo de diana de AMC que, cuando es expuesto, es reconocido por la chaperona citosólica HSPA8 (también conocida como Hsc70) y por cochaperonas que entregan la proteína a monómeros de LAMP2A en la superficie de las células lisosómicas para su translocación por medio del complejo de translocación LAMP2A. La AMC es diferente de la AUTOFAGIA SELECTIVA MEDIADA POR CHAPERONAS, un tipo de MACROAUTOFAGIA selectiva.
Descriptor Portuguese: Autofagia Mediada por Chaperonas
Descriptor French: Autophagie médiée par les chaperonnes
Entry term(s): Autophagy, Chaperone-Mediated
Chaperone Mediated Autophagy
Tree number(s): G04.011.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000080642
Scope note: A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Autophagy (2000-2019)
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59051
Unique ID: D000080642
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/09
Revision Date: 2019/07/08
Chaperone-Mediated Autophagy - Preferred
Concept UI M000648264
Scope note A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.
Preferred term Chaperone-Mediated Autophagy
Entry term(s) Autophagy, Chaperone-Mediated
Chaperone Mediated Autophagy



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