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Descriptor English: Autophagy
Descriptor Spanish: Autofagia
Descriptor autofagia
Entry term(s) RE-fagia
autofagocitosis
lipofagia
nucleofagia
reticulofagia
ribofagia
Scope note: Segregación y degradación de diversos elementos constitutivos del citoplasma mediante su inclusión en CUERPOS MULTIVESICULARES, VACUOLAS o AUTOFAGOSOMAS y su digestión por los LISOSOMAS. Este proceso desempeña un papel importante en la METAMORFOSIS BIOLÓGICA y en la resorción del hueso por los OSTEOCLASTOS. La alteración de la autofagia se asocia a diversas enfermedades, como las ENFERMEDADES NEURODEGENERATIVAS y el cáncer.
Descriptor Portuguese: Autofagia
Descriptor French: Autophagie
Entry term(s): Autophagocytosis
Autophagy, Cellular
Cellular Autophagy
ER Phagy
ER-Phagy
Lipophagy
Nucleophagy
Reticulophagy
Ribophagy
Tree number(s): G04.011
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001343
Scope note: The segregation and degradation of various cytoplasmic constituents via engulfment by MULTIVESICULAR BODIES; VACUOLES; or AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.
Annotation: general or unspecified; note specifics; do not confuse with AUTOPHAGIC CELL DEATH, a form of regulated cell death
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Autolysis (1968-1978)
Lysosomes (1966-1978)
Phagocytosis (1966-1978)
Public MeSH Note: 2006; see AUTOPHAGOCYTOSIS 1991-2005, PHAGOCYTOSIS 1979-1990
History Note: 2006(1979)
DeCS ID: 1351
Unique ID: D001343
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1978/03/20
Revision Date: 2019/07/05
Autophagy - Preferred
Concept UI M0002016
Scope note The segregation and degradation of various cytoplasmic constituents via engulfment by MULTIVESICULAR BODIES; VACUOLES; or AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.
Preferred term Autophagy
Entry term(s) Autophagocytosis
Autophagy, Cellular
Cellular Autophagy
Lipophagy - Narrower
Concept UI M000648269
Scope note Lysosomal degradation of LIPID DROPLETS.
Preferred term Lipophagy
Ribophagy - Narrower
Concept UI M000648272
Scope note Lysosomal degradation of RIBOSOMES.
Preferred term Ribophagy
Reticulophagy - Broader
Concept UI M000648273
Scope note Lysosomal degradation of ENDOPLASMIC RETICULUM by MACROAUTOPHAGY or MICROAUTOPHAGY.
Preferred term Reticulophagy
Entry term(s) ER Phagy
ER-Phagy
Nucleophagy - Narrower
Concept UI M000648948
Preferred term Nucleophagy



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