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Descriptor English: Angiotensin-Converting Enzyme 2
Descriptor Spanish: Enzima Convertidora de Angiotensina 2
Descriptor Portuguese: Enzima de Conversão de Angiotensina 2
Descriptor French: Without translation
Entry term(s): ACE Related Carboxypeptidase
ACE-Related Carboxypeptidase
ACE2 Angiotensin Converting Enzyme Protein 2
ACE2 Angiotensin-Converting Enzyme Protein 2
ACE2 Enzyme
ACE2 Protein
Angiotensin Converting Enzyme 2
Angiotensin Converting Enzyme Related Carboxypeptidase
Angiotensin-Converting Enzyme-Related Carboxypeptidase
Carboxypeptidase, ACE-Related
Carboxypeptidase, Angiotensin-Converting Enzyme-Related
Tree number(s): D08.811.277.656.350.245.042
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000085962
Scope note: A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.17.23
Public MeSH Note: 2021; ACE2 ENZYME was indexed as CARBOXYPEPTIDASES 2000-2006; and PEPTIDYL-DIPEPTIDASE A 2007-2020
History Note: 2021 (2000)
DeCS ID: 59495
Unique ID: D000085962
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/06/09
Angiotensin-Converting Enzyme 2 - Preferred
Concept UI M0370114
Scope note A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.
Preferred term Angiotensin-Converting Enzyme 2
Entry term(s) ACE Related Carboxypeptidase
ACE-Related Carboxypeptidase
ACE2 Angiotensin Converting Enzyme Protein 2
ACE2 Angiotensin-Converting Enzyme Protein 2
ACE2 Enzyme
ACE2 Protein
Angiotensin Converting Enzyme 2
Angiotensin Converting Enzyme Related Carboxypeptidase
Angiotensin-Converting Enzyme-Related Carboxypeptidase
Carboxypeptidase, ACE-Related
Carboxypeptidase, Angiotensin-Converting Enzyme-Related



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