| Descriptor English: | Carboxypeptidase B2 | ||||||
| Descriptor Spanish: |
Carboxipeptidasa B2
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| Descriptor Portuguese: | Carboxipeptidase B2 | ||||||
| Descriptor French: | Carboxypeptidase B2 | ||||||
| Entry term(s): |
Arginine Carboxypeptidase Carboxypeptidase B2, Plasma Carboxypeptidase R Carboxypeptidase U Plasma Carboxypeptidase B2 Plasma Procarboxypeptidase B Procarboxypeptidase U Thrombin Activatable Fibrinolysis Inhibitor Thrombin-Activatable Fibrinolysis Inhibitor Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) |
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| Tree number(s): |
D08.811.277.656.350.245.125 D08.811.277.656.350.555.225 D08.811.277.656.675.555.225 D08.811.277.656.837.092 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D025901 | ||||||
| Scope note: | A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.17.20 | ||||||
| Previous Indexing: |
Carboxypeptidases (1979-2001) Lysine Carboxypeptidase (1994-2001) |
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| Public MeSH Note: | 2015; see CARBOXYPEPTIDASE U 2002-2014; CARBOXYPEPTIDASE U (NM) was indexed under CARBOXYPEPTIDASES 1994-2001; for ARGININE CARBOXYPEPTIDASE see LYSINE CARBOXYPEPTIDASE 1997-2001 |
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| History Note: | 2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001 |
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| DeCS ID: | 36082 | ||||||
| Unique ID: | D025901 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2002/01/01 | ||||||
| Date of Entry: | 2001/07/25 | ||||||
| Revision Date: | 2014/06/06 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Carboxypeptidase B2
- Preferred
Procarboxypeptidase U
- Related but not broader or narrower
| Concept UI |
M0376430 |
| Scope note | A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS. |
| Preferred term | Carboxypeptidase B2 |
| Entry term(s) |
Arginine Carboxypeptidase Carboxypeptidase B2, Plasma Carboxypeptidase R Carboxypeptidase U Plasma Carboxypeptidase B2 Thrombin Activatable Fibrinolysis Inhibitor Thrombin-Activatable Fibrinolysis Inhibitor Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) |
| Concept UI |
M0368256 |
| Preferred term | Procarboxypeptidase U |
| Entry term(s) |
Plasma Procarboxypeptidase B |
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