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Descriptor English: Hemicholinium 3
Descriptor Spanish: Hemicolinio 3
Descriptor hemicolinio 3
Scope note: Potente inhibidor del sistema de recaptación de alta afinidad de la COLINA. Tiene menos efecto sobre el sistema de recaptación de baja afinidad. Debido a que la colina es uno de los componentes de la ACETILCOLINA, el tratamiento con hemicolinio puede agotar la acetilcolina de las terminales colinérgicas. El hemicolinio 3 se utiliza frecuentemente como herramienta de investigación animal y en experimentos 'in vitro'.
Descriptor Portuguese: Hemicolínio 3
Descriptor French: Hémicholinium-3
Entry term(s): Hemicholinium
Tree number(s): D02.092.877.435
D02.675.276.435
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006426
Scope note: A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Neurotransmitter Uptake Inhibitors
Cholinergic Agents
Registry Number: 312-45-8
CAS Type 1 Name: Morpholinium, 2,2'-(1,1'-biphenyl)-4,4'-diylbis(2-hydroxy-4,4-dimethyl)-, dibromide
Previous Indexing: Morpholines (1966-1971)
Public MeSH Note: 72
History Note: 72
DeCS ID: 6575
Unique ID: D006426
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30
Hemicholinium 3 - Preferred
Concept UI M0010073
Scope note A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
Preferred term Hemicholinium 3
Entry term(s) Hemicholinium



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