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Descriptor English: Amyotrophic Lateral Sclerosis
Descriptor Spanish: Esclerosis Amiotrófica Lateral
Descriptor esclerosis lateral amiotrófica
Entry term(s) ELA - esclerosis lateral amiotrófica
enfermedad de Lou Gehrig
enfermedad de la neurona motora de la esclerosis amiotrófica lateral
enfermedad de la neurona motora de la esclerosis lateral amiotrófica
esclerosis amiotrófica lateral
Scope note: Trastorno degenerativo que afecta a las NEURONAS MOTORAS superiores del cerebro y a las neuronas motoras inferiores del tronco cerebral y de la MÉDULA ESPINAL. La enfermedad comienza por lo general después de los 50 años de edad y el proceso suele ser mortal en 3 a 6 años. Las manifestaciones clínicas incluyen debilidad progresiva, atrofia, FASCICULACIONES, hiperrreflexia, DISARTRIA, disfagia y, en último término, parálisis de la función respiratoria. Las características anatomopatológicas incluyen la sustitución de las neuronas motoras por ASTROCITOS fibrosos y atrofia de las RAÍCES NERVIOSAS ESPINALES anteriores y de los tractos corticomedulares. (Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Descriptor Portuguese: Esclerose Lateral Amiotrófica
Descriptor French: Sclérose latérale amyotrophique
Entry term(s): ALS - Amyotrophic Lateral Sclerosis
ALS Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis, Guam Form
Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
Charcot Disease
Dementia With Amyotrophic Lateral Sclerosis
Disease, Guam
Disease, Lou-Gehrigs
Gehrig Disease
Gehrig's Disease
Gehrigs Disease
Guam Disease
Guam Form of Amyotrophic Lateral Sclerosis
Lou Gehrig Disease
Lou Gehrig's Disease
Lou-Gehrigs Disease
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Sclerosis, Amyotrophic Lateral
Tree number(s): C10.228.854.139
C10.574.562.250
C10.574.950.050
C10.668.467.250
C18.452.845.800.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000690
Scope note: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Entry Version: ALS
DeCS ID: 704
Unique ID: D000690
NLM Classification: WE 552
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/04/29
Amyotrophic Lateral Sclerosis - Preferred
Concept UI M0001056
Scope note A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Preferred term Amyotrophic Lateral Sclerosis
Entry term(s) ALS - Amyotrophic Lateral Sclerosis
ALS Amyotrophic Lateral Sclerosis
Charcot Disease
Disease, Lou-Gehrigs
Gehrig Disease
Gehrig's Disease
Gehrigs Disease
Lou Gehrig Disease
Lou Gehrig's Disease
Lou-Gehrigs Disease
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Sclerosis, Amyotrophic Lateral
Amyotrophic Lateral Sclerosis, Guam Form - Narrower
Concept UI M0334022
Preferred term Amyotrophic Lateral Sclerosis, Guam Form
Entry term(s) Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
Disease, Guam
Guam Disease
Guam Form of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Dementia - Related but not broader or narrower
Concept UI M0334021
Preferred term Amyotrophic Lateral Sclerosis With Dementia
Entry term(s) Dementia With Amyotrophic Lateral Sclerosis



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