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Descriptor English: Kernicterus
Descriptor Spanish: Kernicterus
Descriptor kerníctero
Entry term(s) encefalopatía bilirrubínica
encefalopatía hiperbilirrubinémica
kernicterus
Scope note: Término utilizado anatomopatológicamente para describir la tinción con BILIRRUBINA de los GANGLIOS BASALES, el TRONCO DEL ENCÉFALO y el CEREBELO, que describe clínicamente un síndrome asociado con HIPERBILIRRUBINEMIA. Las características clínicas son atetosis, ESPASTICIDAD MUSCULAR o hipotonía, dificultad para fijar la mirada vertical y SORDERA. La bilirrubina no conjugada penetra en el cerebro y actúa como una neurotoxina, con frecuencia se asocia con afecciones que dificultan la función de la BARRERA HEMATOENCEFÁLICA (por ej. SEPSIS). Esta afección se da principalmente en neonatos (NIÑOS, RECIÉN NACIDOS) aunque, de modo infrecuente, puede darse en adultos. (Menkes, Textbook of Child Neurology, 5th ed, p613)
Descriptor Portuguese: Kernicterus
Descriptor French: Ictère nucléaire
Entry term(s): Bilirubin Encephalopathies
Bilirubin Encephalopathy
Encephalopathies, Bilirubin
Encephalopathies, Hyperbilirubinemic
Encephalopathy, Bilirubin
Encephalopathy, Hyperbilirubinemic
Hyperbilirubinemic Encephalopathies
Hyperbilirubinemic Encephalopathy
Tree number(s): C10.228.140.163.480
C15.378.295.502
C16.614.304.502
C18.452.132.480
C20.306.502
C23.550.429.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007647
Scope note: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
DeCS ID: 7813
Unique ID: D007647
NLM Classification: WL 362
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09
Kernicterus - Preferred
Concept UI M0011977
Scope note A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
Preferred term Kernicterus
Entry term(s) Bilirubin Encephalopathies
Bilirubin Encephalopathy
Encephalopathies, Bilirubin
Encephalopathies, Hyperbilirubinemic
Encephalopathy, Bilirubin
Encephalopathy, Hyperbilirubinemic
Hyperbilirubinemic Encephalopathies
Hyperbilirubinemic Encephalopathy



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