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Descriptor English: Anesthetics, Local
Descriptor Spanish: Anestésicos Locales
Descriptor anestésicos locales
Entry term(s) anestésico local
anestésicos bloqueantes de la conducción
Scope note: Fármacos que bloquean la conducción nerviosa cuando se aplican localmente en el tejido nervioso en concentraciones apropiadas. Actúan en cualquier parte del sistema nervioso y en todo tipo de fibras nerviosas. Cuando entran en contacto con un tronco nervioso, estos anestésicos pueden causar parálisis sensitiva y motora de la zona inervada. Su acción es completamente reversible. (Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed). Casi todos los anestésicos locales actúan reduciendo la tendencia a activarse de los canales de sodio dependientes del voltaje.
Descriptor Portuguese: Anestésicos Locais
Descriptor French: Anesthésiques locaux
Entry term(s): Anesthetic, Local
Anesthetics, Conduction Blocking
Anesthetics, Conduction-Blocking
Anesthetics, Topical
Conduction Blocking Anesthetics
Conduction-Blocking Anesthetics
Local Anesthetic
Local Anesthetics
Topical Anesthetics
Tree number(s): D27.505.696.277.100.200
D27.505.696.663.850.025
D27.505.954.427.210.100.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000779
Scope note: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Annotation: see note at ANESTHETICS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
DeCS ID: 790
Unique ID: D000779
NLM Classification: QV 110
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Anesthetics, Local - Preferred
Concept UI M0001169
Scope note Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Preferred term Anesthetics, Local
Entry term(s) Anesthetic, Local
Anesthetics, Conduction Blocking
Anesthetics, Conduction-Blocking
Conduction Blocking Anesthetics
Conduction-Blocking Anesthetics
Local Anesthetic
Local Anesthetics
Anesthetics, Topical - Narrower
Concept UI M0550483
Scope note Anesthetic applied on a specific site of body.
Preferred term Anesthetics, Topical
Entry term(s) Topical Anesthetics



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