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Descriptor in English: Mannich Bases
Descriptor in Spanish: Bases de Mannich
Descriptor in Portuguese: Bases de Mannich
Descriptor in French: Bases de Mannich
Entry term(s): Bases, Mannich
Tree number(s): D02.092.650
D02.522.650
Scope note: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.
Annotation: IM general only
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 91(77); was see under AMINES 1977-90
DeCS UI: 8524
Descriptor UI: D008352
Date Established: 1991/01/01
Date of Entry: 1976/05/19
Revision Date: 1992/05/18
Mannich Bases - Preferred
Concept UI M0012994
Scope note Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.
Preferred term Mannich Bases
Entry term(s) Bases, Mannich



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